A Novel Heme-Thiolate Peroxygenase AaeAPO and Its Implications for C-H Activation Chemistry(English, Hardcover, Wang Xiaoshi)

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Product Description

Language: English

Binding: Hardcover

Publisher: Springer International Publishing AG

Genre: Science

ISBN: 9783319032351, 9783319032351

Pages: 130

In this thesis, Xiaoshi Wang investigates the function and mechanism of a newly discovered heme-thiolate peroxygenase,
AaeAPO. This enzyme class comes from Agrocybe aegerita and is used in the conversion of inert hydrocarbons to alcohols.
Xiaoshi's work focuses on an extracellular P450 enzyme which is not limited in its stability and lack of solubility and
therefore is relevant for widespread industrial use. The author demonstrates that the peroxygenase catalyzes a wide
range of reactions. In some cases the author even describes very difficult transformations in molecules that are highly
inert. Her detailed investigations provide a mechanistic framework for how the peroxygenase catalyzes such a large
number of reactions. A major highlight of this thesis is the identification of key short-lived intermediates in the
catalytic cycle of the peroxygenase, using rapid kinetic and spectroscopic methods, as well as the elucidation of the
thermodynamic properties of these high-energy intermediates. This work adds new insight into an important class of
enzymes.
Language: English
Binding: Hardcover
Publisher: Springer International Publishing AG
Genre: Science
ISBN: 9783319032351, 9783319032351
Pages: 130
Imprint: Springer International Publishing AG
Height: 235 mm
Length: 155 mm
Weight: 3731 gr