A brilliant, groundbreaking report on the dramatic rise of allergic and autoimmune disease, and the controversial
therapies scientists are developing to correct these disorders.
From asthma to Crohn’s disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it
appears that the prevalence of these maladies has increased recently, that’s because it has—to levels never before seen
in human history. These days no fewer than one in five—and likely more—Americans suffers from one of these ailments. We
seem newly, and bafflingly, vulnerable to immune system malfunction. Why? One possibility is that we have systematically
cleaned ourselves to illness; this belief challenges deeply entrenched notions about the value of societal hygiene and
the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have
inevitably arrived at this conclusion. To address this global “epidemic of absence,” they must restore the human
This groundbreaking book explores the promising but controversial “worm therapy”—deliberate infection with parasitic
worms—in development to treat autoimmune disease. It explains why farmers’ children so rarely get hay fever, why allergy
is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes
the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic
disease—that a mother’s inflammatory response imprints on her unborn child, tipping the scales toward allergy.
An Epidemic of Absence is a brilliant, cutting-edge exploration of the dramatic rise of allergic and autoimmune diseases
and the controversial, potentially groundbreaking therapies that scientists are developing to correct these disorders.