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Product Profile The basic neural building blocks become less readily available and are less efficiently utilized as the brain ages. One reason this occurs is because the same age-related changes to the vascular system that diminish heart function can also negatively affect the blood supply to the brain. In fact, many other factors involved in mental decline reflect undesirable changes in the body at large. It would seem that a y body really does help lead to a y mind. Yet although the causes of mental decline are diverse, a few basic changes are common to most forms of deterioration that specifically affect the brain. Reduced synthesis of necessary neurotransmitters, decreased circulation, and diminished cellular efficiency are all the enemies of sound memory and mental clarity. Perhaps surprisingly, phospholipids influence all of these areas critical to brain .* Distinguishing Feature: 250 mg of Citicoline [stabilized CDP Choline (cytidine 5’diphosphocholine)] per Citicoline And How It Is Clinically Supported Citicoline (cytidine 5’-diphosphocholine) is a molecule that consists of cytidine and choline joined together by a diphosphate bridge. Once citicoline is ingested, it is broken down into its component parts, and these readily cross into the brain and central nervous system. Both components are incorporated into the phospholipid fraction of the cell membrane and organelles, such as mitochondria. Once there, the components of citicoline act as precursors for the biosynthesis of structural phospholipids (e. g. phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) in neuronal membranes, support cerebral sm, and stimulate the production of neurotransmitters.* Indeed, increased levels of phosphatidylcholine, noradrenaline, acetylcholine, and dopamine have been observed in animal administered citicoline. * Clinical research has demonstrated a reactivation of brain mitochondrial ATPases and the Na+/K+