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🧠 Elevate your mind & heart with every capsule — don’t get left behind!
THORNE Methyl-Guard Plus delivers a potent blend of active folate (5-MTHF), methylcobalamin B12, and essential B vitamins to optimize methylation, supporting heart health, brain function, and metabolic balance. With 4 rigorous quality tests and trusted by elite athletes and healthcare pros, this gluten-free, vegetarian formula ensures superior absorption and long-term vitality.

















| ASIN | B00O5AHC4S |
| Age Range Description | Adult |
| Allergen Information | Dairy Free, Fish Free, Shellfish Free, Soy Free |
| Best Sellers Rank | #6,518 in Health & Household ( See Top 100 in Health & Household ) #110 in Blended Vitamin & Mineral Supplements #648 in Diet & Sports Nutrition |
| Brand | THORNE |
| Brand Name | THORNE |
| Color | Translucent Light Yellow |
| Container Type | Bottle |
| Customer Reviews | 4.7 out of 5 stars 1,777 Reviews |
| Diet Type | Gluten Free |
| Dosage Form | Capsule |
| Flavor | Unflavored |
| Global Trade Identification Number | 00693749789017 |
| Item Dimensions | 2.38 x 2.38 x 4.23 inches |
| Item Form | Capsule |
| Item Weight | 3.84 ounces |
| Manufacturer | Thorne Research |
| Manufacturer Part Number | SF789 |
| Material Features | Vegetarian |
| Model Name | e Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and Healthy Level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 9 |
| Model Number | No Model |
| Number of Items | 1 |
| Primary Supplement Type | Vitamin-b |
| Product Benefits | Eye Health Support |
| Specific Uses For Product | Heart |
| Supplement Formulation | Individual Supplement |
| UPC | 693749789017 701627510421 884967152206 882855267766 885786045052 |
| Unit Count | 90 Count |
L**Y
Highly recommend.
I am 62 and take 2 vitamins a day per my Dr's instructions. She found that i have the MTHFR deficiency doing a swab test in her office. My body responded really quickly to the vitamin. It has helped me get a lot of water off of my body that i didn't know i was holding. So far 20 pounds of water and that's a lot! I did go through a very short few days where i didn't feel very well but i had read the reviews and instructions and kept taking the vitamins and it past. On the other side of that the energy started to build up. My brain is still 30 but my body isn't 80 any more it's coming down to be of age with energy and ability to accomplish things in a day. I also have a B12 deficiency so i have to take extra B12 because there isn't enough in the vitamin for me but i think because of it I think I'm absorbing it better. I just started my 2nd bottle and have more energy than I've had in 20 years. I never want to run out of this! Highly recommend.
D**S
Works amazing when you really need it and know how to use it.
I starting taking this after getting some (SpectraCell) testing done that said I was deficient in the various B vitamins and I had the MTHFR genetic defect that prevents methylation. I felt like crap for the last decade and my usual doctors weren't of any help. I eat very healthy and eat very well too as I thought that would make me better. I won't go into details but I always knew something was wrong and nothing else worked. Anyway, so i read about methyl folate and methylation, MTHFR etc. and I get this to start to "fix"it. Immediately I felt FAR worse than I ever did before. Headaches, brain fog, extreme fatigue. So I stopped taking it and I go back to the sites and learn this is normal reaction. So then I read you should boost your other B vitamins first without the methyl folate or b12 and then add this back in. So I did with a product called B Minus for about 2 months then I added this product back in. Now 2 months in to taking this I feel like I'm finally waking up and getting more energy and I feel fantastic. No side effects. And a lot of my old symptoms are gone or fading away. I held off writing a review b/c I've been so disappointed after taking so many supplements over the years but this one seems to be actually working. It can take 6 -12 months to see full results and get your levels back to where they should be so I can't imagine how I'll feel by then. I'm going to retest through Spectracell in 6 months and see where my levels are at. If you're not familiar with Spectracell, look into it. Most regular doctors won't have it and it's not covered under insurance. I actually went to a nutritionist to get it done. It's the best decision I've ever made for my health. I'm just sad that it took me so long to find the answers. Good luck to you.
B**T
Customer
Great product and always excellent service.
V**.
Good product
Great product
H**L
Life Changing - Thank you Thorne and all you genetic researchers
Wish these were cheaper as I will have to take them for life, but LIFE CHANGING! If you have the MTHFR gene mutation, I can't recommend this vitamin enough. My 85 year old father started taking these too, and has so much more energy! I've been taking about 6 months now. Personally I suffered from Migraines and mental fog and memory loss, not to mention excessive fatigue needing daily naps. My headaches went away within hours of my first dose, my energy increased and I no longer need daily naps, but most important was the brain fog. I was to the point of not being able to solve problems (and I tutor high school math so that is a big problem). Now I teach and tutor without any cognitive problems. I still don't think my memory is what it used to be but not as bad, and everything else is Sooooo much better. If you find out you have the MTHFR gene mutation, this is the vitamin for you. Regular B vitamins wont do it. My mother's Dr. told her to take large amounts of B12 and Folic Acid (for the same mutation) but this is wrong. You don't need more vitamins, you need the RIGHT vitamins. They need to be in the already Methylated form so your body can use them. I'm homozygous for c677t which means I noticed a drastic difference. If you are only heterozygous, you probably won't notice the drastic difference that my father and I did, but I would still recommend as I think it would make a big impact on your overall health.
J**T
Good product but will change color
I’ve been taking this for almost a yr or maybe 9 mos per my Dr. it has been confusing at times as I fill a weekly box with my supplimants for each day as I take quite a few. I’ve noticed that the capsules turn really dark after being in the box. At first I was sure it was turmeric as I had filled capsules with turmeric and I’m afraid I may have thrown some away which this are way to pricy to throw away. I’ve just recently realized they are changing colors as I knew absolutely I did not put the wrong thing in. I wish the manufacturer would address this as to wheather it affects the potency. Surely it doesn’t. Either way just a heads up that they will change from light to a dark burnt Orange. As long as mine are in the original bottle they stay same. Otherwise I have no complaints.
J**A
good
good
A**R
MTHFR
Needed for some who have the mthfr genetic mutation. Will purchase again.
L**.
Just what the doctor ordered!
Recently I found out I’m anemic and distant to go on medication so I did my research and found this to have all the things I need.
J**N
Methyl-guard plus
Only 5 days of taking it but I feel like it’s doing me good
M**R
good value
good product
R**.
Highly overrated
Good to take supplements, still cannot see the justification of this high price!
Trustpilot
4 days ago
3 days ago